TBX1 Antibody | Affinity Biosciences

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Product:	TBX1 Antibody
Catalog:	AF0327
Description:	Rabbit polyclonal antibody to TBX1
Application:	WB IF/ICC
Reactivity:	Human
Mol.Wt.:	43kDa; 43kD(Calculated).
Uniprot:	O43435
RRID:	AB_2833490

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Secondary Antibodies
Blocking Peptides

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

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100ul	$280	In stock
200ul	$350	In stock

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Related Downloads

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

WB 1:500-1:3000, IF/ICC: 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human

Clonality:

Polyclonal

Specificity:

TBX1 Antibody detects endogenous levels of total TBX1.

RRID:

AB_2833490
Cite Format: Affinity Biosciences Cat# AF0327, RRID:AB_2833490.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

Brachyury; CAFS; CTHM; DGCR; DGS; DORV; T box; T box 1; T box 1 transcription factor; T box 1 transcription factor C; T box protein 1; T box transcription factor TBX 1; T box transcription factor TBX1; T-box protein 1; T-box transcription factor TBX1; TBX 1; TBX 1C; tbx1; TBX1_HUMAN; TBX1C; Testis specific T box protein; Testis-specific T-box protein; TGA; VCFS;

Immunogens

Immunogen:

A synthesized peptide derived from human TBX1, corresponding to a region within C-terminal amino acids.

Uniprot:

O43435(TBX1_HUMAN) >>Visit HPA database.

Gene(ID):

TBX1(6899)

Description:

TBX1 Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries. 3 isoforms of the human protein are produced by alternative splicing.

Sequence:

O43435 TBX1_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLMSAFARSRNPVASPTQPSGTEKGGHVLKDKEVKAETSRNTPEREVELLRDAGGCVNLGLPCPAECQPFNTQGLVAGRTAGDRLC

PTMs - O43435 As Substrate

O43435

Site	PTM Type	Source
T142	Phosphorylation	Uniprot
K202	Ubiquitination	Uniprot
Y255	Phosphorylation	Uniprot
T282	Phosphorylation	Uniprot
S327	Phosphorylation	Uniprot

Research Backgrounds

O43435_TBX1_HUMAN

Function:

Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).

Subcellular Location:

Nucleus.

Subunit Structure:

Interacts with DSCR6.

References

1). Establishment of an induced pluripotent stem cell line (SAHGMUi001-A) from a patient with Netherton syndrome carrying SPINK5 mutation. Stem Cell Research, 2021 (PubMed: 32416580) [IF=1.2]

2). Generation and characterization of an induced pluripotent stem cell line (ZSYYDNi001-A) from a patient with Duchenne muscular dystrophy carrying exon 51 deletion in the DMD gene. Stem Cell Research, 2021 (PubMed: 34619646) [IF=1.2]

Application: IF/ICC Species: Human Sample:

Fig. 1. Characterization of the induced pluripotent stem cell line.

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TBX1 Antibody - #AF0327