VWA5A Antibody - #AF0306
(1)
| Product: | VWA5A Antibody |
| Catalog: | AF0306 |
| Description: | Rabbit polyclonal antibody to VWA5A |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Mol.Wt.: | 86kDa; 86kD(Calculated). |
| Uniprot: | O00534 |
| RRID: | AB_2833470 |
Product Info
Source:
Rabbit
Application:
WB 1:500-1:3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Polyclonal
Specificity:
VWA5A Antibody detects endogenous levels of total VWA5A.
RRID:
AB_2833470
Cite Format: Affinity Biosciences Cat# AF0306, RRID:AB_2833470.
Cite Format: Affinity Biosciences Cat# AF0306, RRID:AB_2833470.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
BCSC 1;BCSC-1;BCSC1;Breast cancer suppressor candidate 1;LHR2A;LOH11CR2A;Loss of heterozygosity 11 chromosomal region 2 gene A;Loss of heterozygosity 11 chromosomal region 2 gene A protein;Ortholog of mouse AW551984;VMA5A_HUMAN;von Willebrand factor A domain containing 5A;von Willebrand factor A domain-containing protein 5A;Vwa5a;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Expression:
O00534 VMA5A_HUMAN:
Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.
Description:
VWA5A May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. 4 isoforms of the human protein are produced by alternative splicing.
Sequence:
- O00534 VMA5A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTPSVVLEMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQLRIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEILAPLQNIYRGPSIPGHPLQLFVFTDGEVTDTFSVIKEVRINRQKHRCFSFGIGEGTSTSLIKGIARASGGTSEFITGKDRMQSKALRTLKRSLQPVVEDVSLSWHLPPGLSAKMLSPEQTVIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFEDKVTFPLQPKPDVNLTIHRLAAKSLLQTKDMGLRETPASDKKDALNLSLESGVISSFTAFIAINKELNKPVQGPLAHRDVPRPILLGASAPLKIKCQSGFRKALHSDRPPSASQPRGELMCYKAKTFQMDDYSLCGLISHKDQHSPGFGENHLVQLIYHQNANGSWDLNEDLAKILGMSLEEIMAAQPAELVDSSGWATILAVIWLHSNGKDLKCEWELLERKAVAWMRAHAGSTMPSVVKAAITFLKSSVDPAIFAF
PTMs - O00534 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T9 | Phosphorylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| K310 | Ubiquitination | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| S485 | Phosphorylation | Uniprot | |
| T489 | Phosphorylation | Uniprot | |
| K525 | Ubiquitination | Uniprot | |
| K597 | Ubiquitination | Uniprot | |
| S617 | Phosphorylation | Uniprot | |
| K621 | Ubiquitination | Uniprot | |
| K623 | Ubiquitination | Uniprot | |
| K630 | Ubiquitination | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| S639 | Phosphorylation | Uniprot | |
| K653 | Ubiquitination | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| Y660 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| S673 | Phosphorylation | Uniprot |
Research Backgrounds
Function:
May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
Tissue Specificity:
Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.
References
1). Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation. Apoptosis, 2021
(PubMed: 33550458)
[IF=7.2]
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