AFfirm™ FN3K Mouse Monoclonal Antibody - #BF8088

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Product: FN3K Mouse Monoclonal Antibody
Catalog: BF8088
Description: Mouse monoclonal antibody to FN3K
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 35 kDa; 35kD(Calculated).
Uniprot: Q9H479

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:1000-1:10000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Monoclonal [AFfirm8088]
Specificity:
FN3K Antibody detects endogenous levels of total FN3K.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2310074G21Rik; Fnsk; Fructosamine 3 kinase; RP23-293H17.4;

Immunogens

Immunogen:
Uniprot:

Q9H479(FN3K_HUMAN) >>Visit HPA database.

Gene(ID):
FN3K(64122)
Expression:
Q9H479 FN3K_HUMAN:

Widely expressed (PubMed:11522682). Expressed in erythrocytes (PubMed:11016445).

Sequence:
MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK

PTMs - Q9H479 As Substrate

Site PTM Type Enzyme
M1 Acetylation
C24 S-Nitrosylation
S97 Phosphorylation
K102 Ubiquitination
K116 Ubiquitination
S258 Phosphorylation
Y263 Phosphorylation
Y296 Phosphorylation
S298 Phosphorylation

Research Backgrounds

Function:

Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines.

Tissue Specificity:

Widely expressed. Expressed in erythrocytes.

Subunit Structure:

Monomer.

Family&Domains:

Belongs to the fructosamine kinase family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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