Phospho-CPI17alpha (Thr38) Antibody - #AF3473
| Product: | Phospho-CPI17alpha (Thr38) Antibody |
| Catalog: | AF3473 |
| Description: | Rabbit polyclonal antibody to Phospho-CPI17alpha (Thr38) |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Rabbit |
| Mol.Wt.: | 22kDa; 17kD(Calculated). |
| Uniprot: | Q96A00 |
| RRID: | AB_2834911 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF3473, RRID:AB_2834911.
Fold/Unfold
17 kDa PKC-potentiated inhibitory protein of PP1; 17-KDa protein; 17kDa PKC potentiated inhibitory protein of PP1; CPI 17 alpha; CPI 17; CPI 17alpha; CPI-17; CPI17; PKC potentiated inhibitory protein of PP1; PKC potentiated inhibitory protein of PP1, 17-KD; PP14A_HUMAN; PPP1INL; Ppp1r14a; Protein kinase C-potentiated inhibitor of protein phosphatase 1, 17-KD; Protein kinase C-potentiated inhibitor protein of 17 kDa; Protein phosphatase 1; Protein phosphatase 1 regulatory (inhibitor) subunit 14A; Protein phosphatase 1 regulatory subunit 14A; Regulatory subunit 14A;
Immunogens
- Q96A00 PP14A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMEADMPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96A00 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R5 | Methylation | Uniprot | |
| S12 | Phosphorylation | O43293 (DAPK3) | Uniprot |
| S16 | Phosphorylation | Uniprot | |
| R19 | Methylation | Uniprot | |
| R21 | Methylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K32 | Methylation | Uniprot | |
| T38 | Phosphorylation | Q05655 (PRKCD) , P17612 (PRKACA) , O75116 (ROCK2) , Q02156 (PRKCE) , O43293 (DAPK3) , Q15139 (PRKD1) , Q13976 (PRKG1) , P17252 (PRKCA) , Q13418 (ILK) , Q05513 (PRKCZ) , Q13153 (PAK1) , P98161 (PKD1) | Uniprot |
| K40 | Methylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S134 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot |
Research Backgrounds
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Cytoplasm.
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
Belongs to the PP1 inhibitor family.
Research Fields
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
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