Phospho-KIF1B (Ser1487) Antibody - #AF2357
Product: | Phospho-KIF1B (Ser1487) Antibody |
Catalog: | AF2357 |
Description: | Rabbit polyclonal antibody to Phospho-KIF1B (Ser1487) |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
Mol.Wt.: | 140, 200kDa; 204kD(Calculated). |
Uniprot: | O60333 |
RRID: | AB_2845371 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF2357, RRID:AB_2845371.
Fold/Unfold
Charcot Marie Tooth neuropathy 2A; CMT 2; CMT 2A; CMT 2A1; CMT2 A; CMT2 A1; CMT2; CMT2A 1; CMT2A; CMT2A1; D4Mil1e; HMSN II; HMSNII; HMSNII, hereditary motor sensory neuropathy II; KIF 1B; KIF1 B; KIF1B p130; KIF1B p204; KIF1Bp130; KIF1Bp204; kinesin family member 1B; Kinesin like protein KIF1B; Klp;
Immunogens
Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.
- O60333 KIF1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDAGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEISRINDLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELNSPPQPCRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVDAILSLNIISAKYLKSSHNSSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMSDTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRERLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSGDIESLVDREKELATKCLQLLTHTFNREFSQVHGSVSDCKLSDISPIGRDPSESSFSSATLTPSSTCPSLVDSRSNSLDQKTPEANSRASSPCPEFEQFQIVPAVETPYLARAGKNEFLNLVPDIEEIRPSSVVSKKGYLHFKEPLYSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRRCPSQSKY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60333 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S2 | Acetylation | Uniprot | |
K7 | Acetylation | Uniprot | |
R11 | Methylation | Uniprot | |
K243 | Ubiquitination | Uniprot | |
K266 | Ubiquitination | Uniprot | |
S274 | Phosphorylation | Uniprot | |
T276 | Phosphorylation | Uniprot | |
T277 | Phosphorylation | Uniprot | |
T301 | Phosphorylation | Uniprot | |
K355 | Ubiquitination | Uniprot | |
T467 | Phosphorylation | Uniprot | |
T522 | Phosphorylation | Uniprot | |
S527 | Phosphorylation | Uniprot | |
K552 | Ubiquitination | Uniprot | |
S572 | Phosphorylation | Uniprot | |
C600 | S-Nitrosylation | Uniprot | |
K646 | Ubiquitination | Uniprot | |
T647 | Phosphorylation | Uniprot | |
S654 | Phosphorylation | Uniprot | |
K693 | Ubiquitination | Uniprot | |
Y707 | Phosphorylation | Uniprot | |
S709 | Phosphorylation | Uniprot | |
K784 | Ubiquitination | Uniprot | |
S892 | Phosphorylation | Uniprot | |
S893 | Phosphorylation | Uniprot | |
K999 | Ubiquitination | Uniprot | |
S1035 | Phosphorylation | Uniprot | |
Y1040 | Phosphorylation | Uniprot | |
S1054 | Phosphorylation | Uniprot | |
S1057 | Phosphorylation | Uniprot | |
T1075 | Phosphorylation | Uniprot | |
K1089 | Ubiquitination | Uniprot | |
K1156 | Ubiquitination | Uniprot | |
S1162 | Phosphorylation | Uniprot | |
S1211 | Phosphorylation | Uniprot | |
K1228 | Ubiquitination | Uniprot | |
T1241 | Phosphorylation | Uniprot | |
S1416 | Phosphorylation | Uniprot | |
S1432 | Phosphorylation | Uniprot | |
S1435 | Phosphorylation | Uniprot | |
S1454 | Phosphorylation | Uniprot | |
S1487 | Phosphorylation | Uniprot | |
K1507 | Ubiquitination | Uniprot | |
S1573 | Phosphorylation | Uniprot | |
T1592 | Phosphorylation | Uniprot | |
S1598 | Phosphorylation | Uniprot | |
S1603 | Phosphorylation | Uniprot | |
S1605 | Phosphorylation | Uniprot | |
S1610 | Phosphorylation | Uniprot | |
S1613 | Phosphorylation | Uniprot | |
S1620 | Phosphorylation | Uniprot | |
T1630 | Phosphorylation | Uniprot | |
S1632 | Phosphorylation | Uniprot | |
S1641 | Phosphorylation | Uniprot | |
S1643 | Phosphorylation | Uniprot | |
S1645 | Phosphorylation | Uniprot | |
T1650 | Phosphorylation | Uniprot | |
S1655 | Phosphorylation | Uniprot | |
S1658 | Phosphorylation | Uniprot | |
S1659 | Phosphorylation | Uniprot | |
T1675 | Phosphorylation | Uniprot | |
K1720 | Acetylation | Uniprot | |
T1764 | Phosphorylation | Uniprot |
Research Backgrounds
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.
Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.
Cytoplasm>Cytoskeleton. Mitochondrion.
Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle.
Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.
Monomer (By similarity). Interacts (via C-terminus end of the kinesin-motor domain) with CHP1; the interaction occurs in a calcium-dependent manner (By similarity). Interacts with KIFBP.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
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