LRPPRC Antibody - #DF12421

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Product: LRPPRC Antibody
Catalog: DF12421
Description: Rabbit polyclonal antibody to LRPPRC
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.: 130 kDa; 158kD(Calculated).
Uniprot: P42704
RRID: AB_2845226

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(92%)
Clonality:
Polyclonal
Specificity:
LRPPRC Antibody detects endogenous levels of total LRPPRC.
RRID:
AB_2845226
Cite Format: Affinity Biosciences Cat# DF12421, RRID:AB_2845226.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

130 kDa leucine-rich protein; gp130; Leucine-rich PPR motif-containing protein; Leucine-rich PPR-motif containing protein; LPPRC_HUMAN; LRP 130; lrpprc; mitochondrial;

Immunogens

Immunogen:
Uniprot:

P42704(LPPRC_HUMAN) >>Visit HPA database.

Gene(ID):
LRPPRC(10128)
Expression:
P42704 LPPRC_HUMAN:

Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes.

Sequence:
MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYAIAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFEFYAQQLRKLRENSS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
92
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P42704 As Substrate

Site PTM Type Enzyme
S23 Phosphorylation
S54 Phosphorylation
S75 Phosphorylation
S80 Phosphorylation
K107 Acetylation
K107 Ubiquitination
R128 Methylation
C130 S-Nitrosylation
K138 Acetylation
K155 Acetylation
K155 Ubiquitination
Y160 Phosphorylation
Y165 Phosphorylation
S180 Phosphorylation
K187 Acetylation
R197 Methylation
Y207 Phosphorylation
S236 Phosphorylation
T269 Phosphorylation
Y270 Phosphorylation
Y277 Phosphorylation
K280 Ubiquitination
K287 Ubiquitination
K292 Acetylation
Y320 Phosphorylation
Y334 Phosphorylation
K396 Acetylation
K453 Ubiquitination
S536 Phosphorylation
S543 Phosphorylation
S593 Phosphorylation
R605 Methylation
Y607 Phosphorylation
K613 Acetylation
K613 Ubiquitination
K617 Sumoylation
K617 Ubiquitination
Y623 Phosphorylation
Y633 Phosphorylation
K649 Acetylation
K649 Ubiquitination
K655 Ubiquitination
T660 Phosphorylation
S661 Phosphorylation
S662 Phosphorylation
S666 Phosphorylation
K726 Acetylation
R739 Methylation
S742 Phosphorylation
K750 Acetylation
K777 Acetylation
K851 Acetylation
K864 Acetylation
K868 Acetylation
S882 Phosphorylation
N903 Phosphorylation
T913 Phosphorylation
S920 Phosphorylation
R929 Methylation
C930 S-Nitrosylation
Y958 Phosphorylation
K980 Ubiquitination
Y1016 Phosphorylation
S1022 Phosphorylation
S1025 Phosphorylation
S1026 Phosphorylation
S1029 Phosphorylation
T1031 Phosphorylation
Y1052 Phosphorylation
Y1070 Phosphorylation
Y1082 Phosphorylation
T1084 Phosphorylation
K1098 Ubiquitination
T1136 Phosphorylation
S1138 Phosphorylation
K1163 Ubiquitination
S1171 Phosphorylation
S1175 Phosphorylation
Y1215 Phosphorylation
Y1220 Phosphorylation
K1224 Acetylation
Y1251 Phosphorylation
C1277 S-Nitrosylation
S1306 Phosphorylation
K1317 Acetylation
Y1321 Phosphorylation
S1323 Phosphorylation
S1327 Phosphorylation
K1332 Acetylation
Y1341 Phosphorylation
T1345 Phosphorylation
K1350 Ubiquitination
Y1382 Phosphorylation

Research Backgrounds

Function:

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).

Subcellular Location:

Mitochondrion. Nucleus>Nucleoplasm. Nucleus inner membrane. Nucleus outer membrane.
Note: Seems to be predominantly mitochondrial.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes.

Subunit Structure:

Interacts with CECR2, HEBP2, MAP1S and UXT. Interacts with PPARGC1A. Interacts with FOXO1 (By similarity). Component of mRNP complexes associated with HNRPA1.

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