Product: Phospho-HPD (Thr382) Antibody
Catalog: AF8609
Source: Rabbit
Application: WB, ELISA(peptide)
Reactivity: Human, Mouse, Rat
Prediction: Rabbit
Mol.Wt.: 45 kD; 45kD(Calculated).
Uniprot: P32754
RRID: AB_2843459

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Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
Reactivity:
Human,Mouse,Rat
Prediction:
Rabbit(100%)
Clonality:
Polyclonal
Specificity:
Phospho-HPD (Thr382) Antibody detects endogenous levels of HPD only when phosphorylated at Thr382.
RRID:
AB_2843459
Cite Format: Affinity Biosciences Cat# AF8609, RRID:AB_2843459.
Purification:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

4 HPPD; 4 hydroxyphenylpyruvate dioxygenase; 4 hydroxyphenylpyruvic acid oxidase; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; GLOD3; glyoxalase domain containing 3; HPD; HPPD_HUMAN; HPPDase; PPD;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Sequence:
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Pig
0
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P32754 As Substrate

Site PTM Type Enzyme
T2 Acetylation
Y4 Phosphorylation
K63 Ubiquitination
Y105 Phosphorylation
K127 Ubiquitination
S211 Phosphorylation
Y221 Phosphorylation
S222 Phosphorylation
S223 Phosphorylation
S226 Phosphorylation
Y232 Phosphorylation
K247 Acetylation
K249 Ubiquitination
S290 Phosphorylation
Y295 Phosphorylation
Y296 Phosphorylation
K297 Ubiquitination
K311 Ubiquitination
T382 Phosphorylation

Research Backgrounds

Function:

Key enzyme in the degradation of tyrosine.

Subunit Structure:

Homodimer.

Family&Domains:

Belongs to the 4HPPD family.

Research Fields

· Metabolism > Metabolism of cofactors and vitamins > Ubiquinone and other terpenoid-quinone biosynthesis.

· Metabolism > Amino acid metabolism > Tyrosine metabolism.

· Metabolism > Amino acid metabolism > Phenylalanine metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

Restrictive clause

 

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