USP51 Antibody - #DF9994
| Product: | USP51 Antibody |
| Catalog: | DF9994 |
| Description: | Rabbit polyclonal antibody to USP51 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Prediction: | Pig, Horse, Rabbit |
| Mol.Wt.: | 80 kDa; 80kD(Calculated). |
| Uniprot: | Q70EK9 |
| RRID: | AB_2843186 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9994, RRID:AB_2843186.
Fold/Unfold
Deubiquitinating enzyme 51; Ubiquitin carboxyl-terminal hydrolase 51; Ubiquitin specific peptidase 51; Ubiquitin thioesterase 51; Ubiquitin thiolesterase 51; Ubiquitin-specific-processing protease 51; UBP51_HUMAN; USP51;
Immunogens
- Q70EK9 UBP51_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAQVRETSLPSGSGVRWISGGGGGASPEEAVEKAGKMEEAAAGATKASSRREAEEMKLEPLQEREPAPEENLTWSSSGGDEKVLPSIPLRCHSSSSPVCPRRKPRPRPQPRARSRSQPGLSAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGDLDGSGDPGGLGDWLLEVEFGQGPTGCSHVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSCICHVCSTHMNRLHSCLSCVFFGCFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQIAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLEKD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q70EK9 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S26 | Phosphorylation | Uniprot | |
| K46 | Acetylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| T359 | Phosphorylation | Uniprot | |
| T382 | Phosphorylation | Uniprot | |
| K567 | Ubiquitination | Uniprot | |
| K597 | Ubiquitination | Uniprot | |
| K604 | Ubiquitination | Uniprot | |
| T611 | Phosphorylation | Uniprot | |
| S679 | Phosphorylation | Uniprot |
Research Backgrounds
Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin.
Chromosome.
Note: Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair.
Expressed in prostate, brain, lung, aorta and kidney.
Interacts with H2A.
Belongs to the peptidase C19 family.
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