PPP4R1 Antibody - #DF9893
| Product: | PPP4R1 Antibody |
| Catalog: | DF9893 |
| Description: | Rabbit polyclonal antibody to PPP4R1 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 107 kDa; 107kD(Calculated). |
| Uniprot: | Q8TF05 |
| RRID: | AB_2843087 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9893, RRID:AB_2843087.
Fold/Unfold
Human clone 23840 mRNA partial cds; MEG1; PP4(Rmeg); Protein phosphatase 4 regulatory subunit 1; Serine/threonine phosphatase 4; Serine/threonine phosphatase 4 regulatory subunit 1;
Immunogens
Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.
- Q8TF05 PP4R1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8TF05 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K53 | Ubiquitination | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| Y453 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| S538 | Phosphorylation | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| K550 | Ubiquitination | Uniprot | |
| C566 | S-Nitrosylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| K612 | Ubiquitination | Uniprot | |
| K643 | Ubiquitination | Uniprot | |
| K730 | Ubiquitination | Uniprot | |
| K803 | Ubiquitination | Uniprot | |
| S806 | Phosphorylation | Uniprot | |
| T816 | Phosphorylation | Uniprot | |
| K887 | Ubiquitination | Uniprot | |
| T892 | Phosphorylation | Uniprot | |
| K926 | Ubiquitination | Uniprot | |
| S935 | Phosphorylation | Uniprot | |
| K937 | Ubiquitination | Uniprot | |
| S944 | Phosphorylation | Uniprot | |
| T945 | Phosphorylation | Uniprot | |
| S947 | Phosphorylation | Uniprot | |
| S948 | Phosphorylation | Uniprot | |
| Y950 | Phosphorylation | Uniprot |
Research Backgrounds
Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.
Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.
Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with HDAC3.
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