Product: STK38L Antibody
Catalog: DF9885
Description: Rabbit polyclonal antibody to STK38L
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.: 54 kDa; 54kD(Calculated).
Uniprot: Q9Y2H1
RRID: AB_2843079

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(92%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(83%)
Clonality:
Polyclonal
Specificity:
STK38L Antibody detects endogenous levels of total STK38L.
RRID:
AB_2843079
Cite Format: Affinity Biosciences Cat# DF9885, RRID:AB_2843079.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

KIAA0965; NDR2; NDR2 protein kinase; nuclear Dbf2 related 2; Nuclear Dbf2 related kinase 2; Nuclear Dbf2-related kinase 2; Serine/threonine protein kinase 38 like; Serine/threonine-protein kinase 38-like; ST38L_HUMAN; Stk38l;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q9Y2H1 ST38L_HUMAN:

Ubiquitously expressed with highest levels observed in the thymus.

Sequence:
MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Pig
92
Xenopus
83
Zebrafish
75
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9Y2H1 As Substrate

Site PTM Type Enzyme
K73 Ubiquitination
T75 Phosphorylation
K94 Ubiquitination
K110 Ubiquitination
Y116 Phosphorylation
K119 Ubiquitination
K123 Ubiquitination
K129 Ubiquitination
K215 Ubiquitination
K224 Ubiquitination
K228 Ubiquitination
T236 Phosphorylation
K239 Ubiquitination
S265 Phosphorylation
K266 Ubiquitination
S282 Phosphorylation Q9Y2H1 (STK38L)
T283 Phosphorylation
T286 Phosphorylation
Y289 Phosphorylation
K355 Ubiquitination
K378 Ubiquitination
K403 Ubiquitination
Y441 Phosphorylation
T442 Phosphorylation Q9Y6E0 (STK24)
Y443 Phosphorylation
T450 Phosphorylation
R452 Methylation
S454 Phosphorylation
K460 Ubiquitination

PTMs - Q9Y2H1 As Enzyme

Substrate Site Source
O60285 (NUAK1) T211 Uniprot
P46937 (YAP1) S127 Uniprot
Q96QF0 (RAB3IP) S288 Uniprot
Q9Y2H1 (STK38L) S282 Uniprot

Research Backgrounds

Function:

Involved in the regulation of structural processes in differentiating and mature neuronal cells.

Subcellular Location:

Cytoplasm. Cytoplasm>Cytoskeleton. Membrane.
Note: Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed with highest levels observed in the thymus.

Subunit Structure:

Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.

Family&Domains:

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Restrictive clause

 

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For Research Use Only.
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