ARHGEF6 Antibody - #DF9865
| Product: | ARHGEF6 Antibody |
| Catalog: | DF9865 |
| Description: | Rabbit polyclonal antibody to ARHGEF6 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 87kDa; 87kD(Calculated). |
| Uniprot: | Q15052 |
| RRID: | AB_2843059 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9865, RRID:AB_2843059.
Fold/Unfold
Alpha Pix; Alpha-Pix; ARHG6_HUMAN; ARHGEF6; COOL 2; COOL-2; COOL2; Mental retardation, X linked 46; MRX46; PAK interacting exchange factor alpha; PAK-interacting exchange factor alpha; PIXA; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor 6; Rho guanine nucleotide exchange factor 6;
Immunogens
- Q15052 ARHG6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15052 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K22 | Ubiquitination | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Q04759 (PRKCQ) | Uniprot |
| K227 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| Y470 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Q04759 (PRKCQ) | Uniprot |
| Y492 | Phosphorylation | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| T504 | Phosphorylation | Uniprot | |
| S552 | Phosphorylation | Uniprot | |
| K558 | Ubiquitination | Uniprot | |
| S561 | Phosphorylation | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| S565 | Phosphorylation | Uniprot | |
| S569 | Phosphorylation | Uniprot | |
| T573 | Phosphorylation | Uniprot | |
| S592 | Phosphorylation | Uniprot | |
| Y608 | Phosphorylation | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| Y614 | Phosphorylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| K627 | Acetylation | Uniprot | |
| T635 | Phosphorylation | Uniprot | |
| K638 | Ubiquitination | Uniprot | |
| S640 | Phosphorylation | Uniprot | |
| Y644 | Phosphorylation | Uniprot | |
| K648 | Ubiquitination | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| T650 | Phosphorylation | Uniprot | |
| K661 | Ubiquitination | Uniprot | |
| Y666 | Phosphorylation | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| K682 | Ubiquitination | Uniprot | |
| S684 | Phosphorylation | P17612 (PRKACA) , Q13976 (PRKG1) | Uniprot |
| K695 | Ubiquitination | Uniprot | |
| T701 | Phosphorylation | Uniprot | |
| S703 | Phosphorylation | Uniprot | |
| K712 | Ubiquitination | Uniprot | |
| S713 | Phosphorylation | Uniprot | |
| T717 | Phosphorylation | Uniprot | |
| Y719 | Phosphorylation | Uniprot | |
| K722 | Ubiquitination | Uniprot | |
| K736 | Ubiquitination | Uniprot | |
| K751 | Acetylation | Uniprot | |
| K758 | Ubiquitination | Uniprot |
Research Backgrounds
Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Cell projection>Lamellipodium.
Ubiquitous.
Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.
Research Fields
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Cancers: Specific types > Pancreatic cancer. (View pathway)
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