PTPRK Antibody - #DF9842
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9842, RRID:AB_2843036.
Fold/Unfold
dJ480J14.2.1; DKFZp686C2268; DKFZp779N1045; OTTHUMP00000017180; OTTHUMP00000017181; OTTHUMP00000017182; OTTHUMP00000017187; OTTHUMP00000040306; Protein tyrosine phosphatase kappa; Protein tyrosine phosphatase kappa precursor; Protein tyrosine phosphatase receptor type K; Protein tyrosine phosphatase receptor type kappa; Protein-tyrosine phosphatase kappa; PTPK; PTPkappa; Ptprk; PTPRK_HUMAN; R PTP kappa; R-PTP-kappa; Receptor type tyrosine protein phosphatase kappa; Receptor-type tyrosine-protein phosphatase kappa;
Immunogens
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
- Q15262 PTPRK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15262 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K194 | Ubiquitination | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| T357 | Phosphorylation | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| N416 | N-Glycosylation | Uniprot | |
| K476 | Ubiquitination | Uniprot | |
| T485 | Phosphorylation | Uniprot | |
| K778 | Acetylation | Uniprot | |
| T790 | Phosphorylation | Uniprot | |
| Y805 | Phosphorylation | Uniprot | |
| S828 | Phosphorylation | Uniprot | |
| Y831 | Phosphorylation | Uniprot | |
| S835 | Phosphorylation | Uniprot | |
| Y849 | Phosphorylation | Uniprot | |
| T854 | Phosphorylation | Uniprot | |
| S856 | Phosphorylation | Uniprot | |
| Y858 | Phosphorylation | Uniprot | |
| T860 | Phosphorylation | Uniprot | |
| Y916 | Phosphorylation | Uniprot | |
| Y922 | Phosphorylation | Uniprot | |
| Y940 | Phosphorylation | Uniprot | |
| Y945 | Phosphorylation | Uniprot | |
| Y1158 | Phosphorylation | Uniprot | |
| K1174 | Ubiquitination | Uniprot | |
| T1184 | Phosphorylation | Uniprot | |
| Y1294 | Phosphorylation | Uniprot | |
| K1360 | Ubiquitination | Uniprot | |
| K1415 | Ubiquitination | Uniprot |
Research Backgrounds
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
This protein undergoes proteolytic processing.
Cell junction>Adherens junction. Cell membrane>Single-pass type I membrane protein.
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
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