RASIP1 Antibody - #DF9810
| Product: | RASIP1 Antibody |
| Catalog: | DF9810 |
| Description: | Rabbit polyclonal antibody to RASIP1 |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 103 kDa; 103kD(Calculated). |
| Uniprot: | Q5U651 |
| RRID: | AB_2843004 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9810, RRID:AB_2843004.
Fold/Unfold
FLJ20401; Rain; RAIN protein fragment; RAIN_HUMAN; Ras interacting protein 1; Ras-interacting protein 1; RASIP 1; RASIP1; RASIP1 protein;
Immunogens
- Q5U651 RAIN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPLPPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGTGTTGSSGAGGPGTPGGAQRWASEKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEALERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQELWRARPGWARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASPGPGTGSGAPAGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGTADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGNSSGRGGSPAPYVDTFLNAPDILPRHCTVRAGPEHPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLGEHFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIVRAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLCVPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVATSP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q5U651 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S11 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S50 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| T111 | Phosphorylation | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| Y389 | Phosphorylation | Uniprot | |
| T401 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| Y537 | Phosphorylation | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| S833 | Phosphorylation | Uniprot | |
| T844 | Phosphorylation | Uniprot | |
| S962 | Phosphorylation | Uniprot |
Research Backgrounds
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
Cytoplasm>Perinuclear region. Golgi apparatus>Golgi stack.
Note: Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.
Highly expressed in heart. Detected at lower levels in placenta and pancreas.
Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2. Interacts with MYH9 and ARHGAP29 (By similarity).
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