HCN3 Antibody - #DF9770
| Product: | HCN3 Antibody |
| Catalog: | DF9770 |
| Description: | Rabbit polyclonal antibody to HCN3 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Dog |
| Mol.Wt.: | 86 kDa; 86kD(Calculated). |
| Uniprot: | Q9P1Z3 |
| RRID: | AB_2842965 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9770, RRID:AB_2842965.
Fold/Unfold
Hcn3; HCN3_HUMAN; hyperpolarization activated cyclic nucleotide-gated potassium channel 3; KIAA1535; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3;
Immunogens
- Q9P1Z3 HCN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9P1Z3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S61 | Phosphorylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| Y387 | Phosphorylation | Uniprot | |
| S655 | Phosphorylation | Uniprot | |
| T678 | Phosphorylation | Uniprot |
Research Backgrounds
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.
Cell membrane>Multi-pass membrane protein.
Detected in brain.
Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Interacts with KCTD3 and PEX5L.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Belongs to the potassium channel HCN family.
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