KCNS1 Antibody - #DF9768
| Product: | KCNS1 Antibody |
| Catalog: | DF9768 |
| Description: | Rabbit polyclonal antibody to KCNS1 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Rabbit, Dog |
| Mol.Wt.: | 58 kDa; 58kD(Calculated). |
| Uniprot: | Q96KK3 |
| RRID: | AB_2842963 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9768, RRID:AB_2842963.
Fold/Unfold
Delayed rectifier K(+) channel alpha subunit 1; Delayed-rectifier K(+) channel alpha subunit 1; K+ voltage gated channel, subfamily S, 1; KCNS1; KCNS1_HUMAN; KV9.1; OTTHUMP00000031783; potassium voltage gated channel delayed rectifier protein; potassium voltage gated channel delayed rectifier protein S1; potassium voltage gated channel, delayed rectifier, subfamily S, member 1; Potassium voltage-gated channel subfamily S member 1; voltage gated potassium channel protein Kv9.1; Voltage gated potassium channel subunit Kv9.1; Voltage-gated potassium channel subunit Kv9.1;
Immunogens
Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis (PubMed:10484328).
- Q96KK3 KCNS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96KK3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S28 | Phosphorylation | Uniprot | |
| T29 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot |
Research Backgrounds
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
Cell membrane>Multi-pass membrane protein.
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:10484328).
Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis.
Heterotetramer with KCNB1. Heterotetramer with KCNB2 (By similarity). Does not form homomultimers.
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
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