PLSCR2 Antibody - #DF9755

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Product: PLSCR2 Antibody
Catalog: DF9755
Description: Rabbit polyclonal antibody to PLSCR2
Application: WB
Reactivity: Human, Mouse
Mol.Wt.: 34 kDa; 34kD(Calculated).
Uniprot: Q9NRY7
RRID: AB_2842950

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
PLSCR2 Antibody detects endogenous levels of total PLSCR2.
RRID:
AB_2842950
Cite Format: Affinity Biosciences Cat# DF9755, RRID:AB_2842950.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Ca(2+)-dependent phospholipid scramblase 2; PL scramblase 2;

Immunogens

Immunogen:
Uniprot:

Q9NRY7(PLS2_HUMAN) >>Visit HPA database.

Gene(ID):
PLSCR2(57047)
Expression:
Q9NRY7 PLS2_HUMAN:

Expression of isoform 1 seems restricted to testis.

Sequence:
MRSWNSLFCLNSSRPPGHIVYPKHQAGHTGKQADHLGSQAFYPGRQHDYLVPPAGTAGIPVQNQPGRPEGVPWMPAPPPPLNCPPGLEYLSQIDMILIHQQIELLEVLFSFESSNMYEIKNSFGQRIYFAAEDTNFCIRNCCGRSRPFTLRITDNVGREVITLERPLRCNCCCCPCCLQEIEIQAPPGVPVGYVTQTWHPCLTKFTIKNQKREDVLKISGPCIVCSCIAGVDFEITSLDEQIVVGRISKHWSGFLREAFTDADNFGIQFPRDLDVKMKAVMIGACFLIDYMFFERTR

PTMs - Q9NRY7 As Substrate

Site PTM Type Enzyme
K120 Ubiquitination
T296 Phosphorylation

Research Backgrounds

Function:

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.

Subcellular Location:

Membrane>Single-pass type II membrane protein.

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expression of isoform 1 seems restricted to testis.

Family&Domains:

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.

Belongs to the phospholipid scramblase family.

Restrictive clause

 

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