PLSCR1 Antibody - #DF9754
| Product: | PLSCR1 Antibody |
| Catalog: | DF9754 |
| Description: | Rabbit polyclonal antibody to PLSCR1 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 35 kDa; 35kD(Calculated). |
| Uniprot: | O15162 |
| RRID: | AB_2842949 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9754, RRID:AB_2842949.
Fold/Unfold
Ca(2+) dependent phospholipid scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MM1 cell-derived transplantability-associated gene 1b, mouse, homolog of; MmTRA1a; MmTRA1b; Nor1; Phospholipid scramblase 1; PL scramblase 1; PLS1_HUMAN; PLSCR 1; Plscr1; Scramblase1; Tra1; Tra1a; Tra1b; Transplantability-associated protein 1; Tras1; Tras2;
Immunogens
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
- O15162 PLS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
PTMs - O15162 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y69 | Phosphorylation | P12931 (SRC) , P00519 (ABL1) , A0A173G4P4 (Abl fusion) | Uniprot |
| Y74 | Phosphorylation | A0A173G4P4 (Abl fusion) , P00519 (ABL1) , P12931 (SRC) | Uniprot |
| K132 | Ubiquitination | Uniprot | |
| T161 | Phosphorylation | Q05655 (PRKCD) | Uniprot |
| K223 | Ubiquitination | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| K261 | Ubiquitination | Uniprot |
Research Backgrounds
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
Phosphorylated by OXSR1 in the presence of RELT.
Cell membrane>Single-pass type II membrane protein. Membrane>Lipid-anchor>Cytoplasmic side. Nucleus. Cytoplasm. Cytoplasm>Perinuclear region.
Note: Localizes to the perinuclear region in the presence of RELT.
Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
Interacts with ABL. Interacts with RELT, RELL1 and RELL2. Interacts with OXSR1 in the presence of RELT.
The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
Belongs to the phospholipid scramblase family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.