OAZ3 Antibody - #DF9726
| Product: | OAZ3 Antibody |
| Catalog: | DF9726 |
| Description: | Rabbit polyclonal antibody to OAZ3 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 27 kDa, 20 kDa; 27kD(Calculated). |
| Uniprot: | Q9UMX2 |
| RRID: | AB_2842921 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9726, RRID:AB_2842921.
Fold/Unfold
Antizyme 3; AZ3; OAZ t; OAZ3; OAZ3_HUMAN; ODC-Az 3; Ornithine decarboxylase antizyme 3; RP11-98D18.13-004; Testicular secretory protein Li 31; TISP15;
Immunogens
- Q9UMX2 OAZ3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UMX2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y54 | Phosphorylation | Uniprot | |
| S56 | Phosphorylation | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| Y197 | Phosphorylation | Uniprot |
Research Backgrounds
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).
Nucleus. Cytoplasm.
Testis specific.
Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1. Interacts with GGN (By similarity).
Belongs to the ODC antizyme family.
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