GPM6A Antibody - #DF9699
| Product: | GPM6A Antibody |
| Catalog: | DF9699 |
| Description: | Rabbit polyclonal antibody to GPM6A |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 31 kDa; 31kD(Calculated). |
| Uniprot: | P51674 |
| RRID: | AB_2842894 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9699, RRID:AB_2842894.
Fold/Unfold
GPM6A; GPM6A_HUMAN; M6a; Neuronal membrane glycoprotein M6-a; Neuronal membrane glycoprotein M6-a,;
Immunogens
- P51674 GPM6A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51674 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T10 | Phosphorylation | Uniprot | |
| Y251 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| Y277 | Phosphorylation | Uniprot |
Research Backgrounds
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
Cell membrane>Multi-pass membrane protein. Cell projection>Axon. Cell projection>Growth cone. Cell projection>Dendritic spine. Cell projection>Filopodium. Cell projection>Neuron projection.
Note: Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity).
Interacts with OPRM1.
Belongs to the myelin proteolipid protein family.
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