NAV3 Antibody - #DF9696

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Product: NAV3 Antibody
Catalog: DF9696
Description: Rabbit polyclonal antibody to NAV3
Application: WB
Reactivity: Human
Prediction: Pig, Zebrafish, Bovine, Horse, Rabbit, Dog, Chicken
Mol.Wt.: 256 kDa; 256kD(Calculated).
Uniprot: Q8IVL0
RRID: AB_2842891

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Rabbit(100%), Dog(100%), Chicken(100%)
Clonality:
Polyclonal
Specificity:
NAV3 Antibody detects endogenous levels of total NAV3.
RRID:
AB_2842891
Cite Format: Affinity Biosciences Cat# DF9696, RRID:AB_2842891.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

KIAA0938; NAV 3; NAV3; NAV3_HUMAN; Neuron navigator 3; POMFIL1; Pore membrane and/or filament-interacting-like protein 1; Steerin 3; Steerin-3; STEERIN3; Unc 53 homolog 3; Unc-53 homolog 3; unc53H3;

Immunogens

Immunogen:
Uniprot:

Q8IVL0(NAV3_HUMAN) >>Visit HPA database.

Gene(ID):
NAV3(89795)
Expression:
Q8IVL0 NAV3_HUMAN:

Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.

Sequence:
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKSTCEFGEKKPLQGKAKEKEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPPSEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGSSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQSSSGVNGNVQPPSTAGQPPASAIPSPSASKPWRSKSMNVKHSATSTMLTVKQSSTATSPTPSSDRLKPPVSEGVKTAPSGQKSMLEKFKLVNARTALRPPQPPSSGPSDGGKDDDAFSESGEMEGFNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKNKVCTEKPVKEEKDQVTEMAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTVKQTISPGSTASKESEKFRTTKGSPSQSLSKPITMEKASASSCPAPLEGREAGQASPSGSCTMTVAQSSGQSTGNGAVQLPQQQQHSHPNTATVAPFIYRAHSENEGTALPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTSRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTSRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSSEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLNRIPDTATSRDIIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLRTDSEKRSTTDETWDSPEELKKPEEDFDSHGDAGGKWKTVSSGLPEDPEKAGQKASLSVSQTGSWRRGMSAQGGAPSRQKAGTSALKTPGKTDDAKASEKGKAPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATSSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGAQGLRQPGSKYPDIASPTFRRLFGAKAGGKSASAPNTEGVKSSSVMPSPSTTLARQGSLESPSSGTGSMGSAGGLSGSSSPLFNKPSDLTTDVISLSHSLASSPASVHSFTSGGLVWAANMSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSAAGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTAKPTRPPSESSSSTSSSSSRQSLGLSLNNLNITEAVSSDILLDDAGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSDCIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTDTEGDPLMNMLMKLQEAANYSSTQSCDSESTSHHEDILDSSLESTL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Zebrafish
100
Chicken
100
Rabbit
100
Sheep
0
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8IVL0 As Substrate

Site PTM Type Enzyme
K93 Ubiquitination
K97 Ubiquitination
S136 Phosphorylation
S261 Phosphorylation
S275 Phosphorylation
T344 Phosphorylation
T355 Phosphorylation
S428 Phosphorylation
T480 Phosphorylation
K485 Sumoylation
T512 Phosphorylation
T513 Phosphorylation
S542 Phosphorylation
R555 Methylation
S560 Phosphorylation
S639 Phosphorylation
T644 Phosphorylation
S648 Phosphorylation
S651 Phosphorylation
S654 Phosphorylation
T782 Phosphorylation
S797 Phosphorylation
T859 Phosphorylation
S980 Phosphorylation
S984 Phosphorylation
S988 Phosphorylation
S1037 Phosphorylation
S1039 Phosphorylation
S1044 Phosphorylation
S1045 Phosphorylation
S1063 Phosphorylation
S1064 Phosphorylation
S1071 Phosphorylation
T1080 Phosphorylation
T1092 Phosphorylation
T1112 Phosphorylation
S1113 Phosphorylation
S1117 Phosphorylation
S1128 Phosphorylation
S1129 Phosphorylation
S1137 Phosphorylation
R1152 Methylation
S1164 Phosphorylation
S1167 Phosphorylation
S1170 Phosphorylation
S1176 Phosphorylation
S1186 Phosphorylation
S1189 Phosphorylation
S1190 Phosphorylation
T1193 Phosphorylation
T1197 Phosphorylation
S1207 Phosphorylation
S1211 Phosphorylation
S1213 Phosphorylation
S1217 Phosphorylation
S1245 Phosphorylation
T1247 Phosphorylation
T1420 Phosphorylation
S1431 Phosphorylation
S1446 Phosphorylation
S1448 Phosphorylation
T1449 Phosphorylation
S1459 Phosphorylation
S1463 Phosphorylation
S1465 Phosphorylation
S1468 Phosphorylation
S1536 Phosphorylation
S1669 Phosphorylation
S1670 Phosphorylation
S1730 Phosphorylation
S1743 Phosphorylation
T1815 Phosphorylation
S1923 Phosphorylation
S1941 Phosphorylation
Y2064 Phosphorylation
Y2072 Phosphorylation
K2076 Acetylation
K2080 Acetylation
S2096 Phosphorylation
Y2280 Phosphorylation
K2282 Methylation

Research Backgrounds

Function:

May regulate IL2 production by T-cells. May be involved in neuron regeneration.

Subcellular Location:

Nucleus outer membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.

Family&Domains:

Belongs to the Nav/unc-53 family.

Restrictive clause

 

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