NAV2 Antibody - #DF9695

(3)  
Product: NAV2 Antibody
Catalog: DF9695
Description: Rabbit polyclonal antibody to NAV2
Application: WB IHC IF/ICC
Reactivity: Human
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 268 kDa; 268kD(Calculated).
Uniprot: Q8IVL1
RRID: AB_2842890

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(83%)
Clonality:
Polyclonal
Specificity:
NAV2 Antibody detects endogenous levels of total NAV2.
RRID:
AB_2842890
Cite Format: Affinity Biosciences Cat# DF9695, RRID:AB_2842890.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

5330421F07Rik; AU067780; FLJ10633; FLJ11030; FLJ23707; HELAD1; Helicase, APC down regulated 1; KIAA1419; mCG 145366; mKIAA3015; NAV 2; Neuron navigator 2; POMFIL2; Pore membrane and/or filament interacting like protein 2; RAINB1; RAINB2; Retinoic acid inducible gene in neuroblastoma 1; Retinoic acid inducible in neuroblastoma 1; Steerin 2; STEERIN2; Unc 53 homolog 2; Unc53H2;

Immunogens

Immunogen:
Uniprot:

Q8IVL1(NAV2_HUMAN) >>Visit HPA database.

Gene(ID):
NAV2(89797)
Expression:
Q8IVL1 NAV2_HUMAN:

Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.

Sequence:
MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTYPSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDTQIYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCPKNRSQMIENIDACLNFLAAKGINIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQPQKQHLSSPLPPAVSQVAGAPSQCQAGTPQQQVPVTPQAPCQPHQPAPHQQSKAQAEMQSSASSKDSSQSKIIRFTLGQKKISRLPGPTARVSAAGSEAKTRGGSTTANNRRSQSFNNYDKSKPVTSPPPPPSSHEKEPLASSASSHPGMSDNAPASLESGSSSTPTNCSTSSAIPQPGAATKPWRSKSLSVKHSATVSMLSVKPPGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGPGSRDTSCERLETLPSFEESEELEAASRMLTTVGPASSSPKIALKGIAQRTFSRALTNKKSSLKGNEKEKEKQQREKDKEKSKDLAKRASVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGGKLNSAKKEPMAPSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDGRHSSSSSSLASSEGKGPGGTTLNHSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAPFLYRSQTDTEGNVTAESSSTGVSVEPSHFTKTGQPALEELTGEDPEARRLRTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEMSGRSILSLTGRPTPLSWRLGQSSPRLQAGDAPSMGNGYPPRANASRFINTESGRYVYSAPLRRQLASRGSSVCHVDVSDKAGDEMDLEGISMDAPGYMSDGDVLSKNIRTDDITSGYMTDGGLGLYTRRLNRLPDGMAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKMEPGSKWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGVTVTSRSATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNLQYRSLPRPSKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGISSDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATAENMKNSVVISNPHATMTQQGNLDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASSKDDSLTPFVRTNSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDAKEWLRSHSAGGLQDTAANSPFSSGSSVTSPSGTRFNFSQLASPTTVTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEESWEKSSVDNFVSRLHSSLHFSLPLFHHARYELVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLPSSPKLPHNGSTGSTPLLRNSHSNSLISECMDSEAETVMQLRNELRDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLKSESQGSGCSRAPSQVSISASPRQSMGLSQHSLNLTESTSLDMLLDDTGECSARKEGGRHVKIVVSFQEEMKWKEDSRPHLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVSQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTISVTVKGLAENSLDSLVFESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFNVDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNCKYHKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNMELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRRAPWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVGFDGYSMPREGSTSKQMPPSDAEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILDSSLESTL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Xenopus
83
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8IVL1 As Substrate

Site PTM Type Enzyme
S311 Phosphorylation
K422 Acetylation
K427 Acetylation
S458 Phosphorylation
S469 Phosphorylation
S479 Phosphorylation
S481 Phosphorylation
R496 Methylation
S524 Phosphorylation
S548 Phosphorylation
S564 Phosphorylation
S599 Phosphorylation
S633 Phosphorylation
S856 Phosphorylation
Y906 Phosphorylation
Y915 Phosphorylation
S1008 Phosphorylation
S1015 Phosphorylation
S1019 Phosphorylation
S1021 Phosphorylation
K1024 Acetylation
K1030 Acetylation
S1055 Phosphorylation
S1059 Phosphorylation
T1075 Phosphorylation
S1104 Phosphorylation
S1113 Phosphorylation
S1115 Phosphorylation
S1120 Phosphorylation
S1121 Phosphorylation
T1135 Phosphorylation
K1146 Methylation
K1147 Methylation
S1149 Phosphorylation
S1151 Phosphorylation
T1159 Phosphorylation
S1161 Phosphorylation
T1164 Phosphorylation
T1166 Phosphorylation
T1171 Phosphorylation
S1190 Phosphorylation
S1191 Phosphorylation
Y1202 Phosphorylation
S1215 Phosphorylation
S1232 Phosphorylation
S1236 Phosphorylation
S1245 Phosphorylation
S1263 Phosphorylation
S1264 Phosphorylation
S1279 Phosphorylation
S1280 Phosphorylation
S1284 Phosphorylation
S1287 Phosphorylation
S1301 Phosphorylation
S1302 Phosphorylation
Y1314 Phosphorylation
S1319 Phosphorylation
T1321 Phosphorylation
S1365 Phosphorylation
S1372 Phosphorylation
S1375 Phosphorylation
S1376 Phosphorylation
S1388 Phosphorylation
S1480 Phosphorylation
S1484 Phosphorylation
S1488 Phosphorylation
S1494 Phosphorylation
T1495 Phosphorylation
S1502 Phosphorylation
T1510 Phosphorylation
T1519 Phosphorylation
K1531 Ubiquitination
S1536 Phosphorylation
S1538 Phosphorylation
T1545 Phosphorylation
S1549 Phosphorylation
T1558 Phosphorylation
S1559 Phosphorylation
S1582 Phosphorylation
T1589 Phosphorylation
S1591 Phosphorylation
S1593 Phosphorylation
Y1602 Phosphorylation
T1603 Phosphorylation
S1610 Phosphorylation
S1611 Phosphorylation
S1613 Phosphorylation
S1703 Phosphorylation
T1732 Phosphorylation
S1737 Phosphorylation
T1776 Phosphorylation
S1799 Phosphorylation
S1800 Phosphorylation
K1825 Acetylation
K1826 Acetylation
S1854 Phosphorylation
S1856 Phosphorylation
S1877 Phosphorylation
K1917 Acetylation
S1970 Phosphorylation
S1973 Phosphorylation
S1975 Phosphorylation
S1977 Phosphorylation
K2048 Acetylation
S2333 Phosphorylation
T2338 Phosphorylation
Y2364 Phosphorylation
Y2381 Phosphorylation
T2433 Phosphorylation
S2440 Phosphorylation
S2474 Phosphorylation

Research Backgrounds

Function:

Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.

Family&Domains:

Belongs to the Nav/unc-53 family.

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