ESCO1 Antibody - #DF9657
| Product: | ESCO1 Antibody |
| Catalog: | DF9657 |
| Description: | Rabbit polyclonal antibody to ESCO1 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Horse, Dog |
| Mol.Wt.: | 95 kDa; 95kD(Calculated). |
| Uniprot: | Q5FWF5 |
| RRID: | AB_2842853 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9657, RRID:AB_2842853.
Fold/Unfold
A930014I12Rik; CTF; CTF7 homolog 1; CTF7, S. cerevisiae, homolog of, 1; ECO1; ECO1 homolog 1; ECO1, S. cerevisiae, homolog of, 1; EFO1; EFO1p; ESCO1; ESCO1_HUMAN; ESO1; ESO1 homolog 1; ESO1, S. pombe, homolog of, 1; Establishment factor like protein 1; Establishment factor ortholog 1; Establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; Establishment of cohesion 1, S. cerevisiae, homolog of; establishment of sister chromatid cohesion N-acetyltransferase 1; hEFO1; HGNC:24645; KIAA1911; N acetyltransferase ESCO1; N-acetyltransferase ESCO1;
Immunogens
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
- Q5FWF5 ESCO1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q5FWF5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K9 | Acetylation | Uniprot | |
| K17 | Acetylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| T89 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| S186 | Phosphorylation | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| S412 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| T529 | Phosphorylation | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| T706 | Phosphorylation | Uniprot |
Research Backgrounds
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
Phosphorylated during mitosis, when associated with chromosomes.
Nucleus. Chromosome.
Note: Nuclear at interphase, associated with chromosomes during mitosis.
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
The subunit structure is controversial. Monomer. Homodimer.
The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.
Belongs to the acetyltransferase family. ECO subfamily.
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