GAS8 Antibody - #DF9545
| Product: | GAS8 Antibody |
| Catalog: | DF9545 |
| Description: | Rabbit polyclonal antibody to GAS8 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 56 kDa; 56kD(Calculated). |
| Uniprot: | O95995 |
| RRID: | AB_2842741 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9545, RRID:AB_2842741.
Fold/Unfold
Growth arrest specific protein 8; MGC138326; GAS 11; GAS 8; GAS-11; GAS-8; GAS11; Gas8; GAS8_HUMAN; Growth arrest specific 11; Growth arrest specific 8; Growth arrest specific protein 11; Growth arrest-specific protein 11; Growth arrest-specific protein 8;
Immunogens
Expressed in respiratory epithelial cells (at protein level) (PubMed:26387594). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney (PubMed:9790751).
- O95995 DRC4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95995 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y51 | Phosphorylation | Uniprot | |
| K125 | Acetylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| Y300 | Phosphorylation | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| T476 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity).
Cytoplasm. Cytoplasm>Cytoskeleton. Cell projection>Cilium>Flagellum. Cytoplasm>Cytoskeleton>Cilium axoneme. Cytoplasm>Cytoskeleton>Cilium basal body. Golgi apparatus. Cell projection>Cilium. Cytoplasm>Cytoskeleton>Flagellum axoneme.
Note: Associates with microtubules (PubMed:10969087). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity).
Expressed in respiratory epithelial cells (at protein level). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney.
Component of the nexin-dynein regulatory complex (N-DRC). Interacts with microtubules (By similarity). Interacts with SMO. Interacts (via coiled-coil domains) with RAB3B (in GTP-bound form) (By similarity).
Belongs to the DRC4 family.
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