FBLN1 Antibody - #DF9516
| Product: | FBLN1 Antibody |
| Catalog: | DF9516 |
| Description: | Rabbit polyclonal antibody to FBLN1 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 77 kDa; 77kD(Calculated). |
| Uniprot: | P23142 |
| RRID: | AB_2842712 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9516, RRID:AB_2842712.
Fold/Unfold
Basement membrane protein 90; BM 90; FBLN; Fbln1; FBLN1_HUMAN; FIBL 1; FIBL-1; FIBL1; Fibulin 1; Fibulin-1;
Immunogens
Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
- P23142 FBLN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P23142 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T45 | Phosphorylation | Uniprot | |
| K48 | Acetylation | Uniprot | |
| T56 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| N98 | N-Glycosylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| Y175 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| Y252 | Phosphorylation | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| R611 | Methylation | Uniprot | |
| Y651 | Phosphorylation | Uniprot | |
| T656 | Phosphorylation | Uniprot |
Research Backgrounds
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
Secreted>Extracellular space>Extracellular matrix.
Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP and FGB. Interacts with FBLN7 (By similarity). Interacts with CCN3.
(Microbial infection) Interacts with human papillomavirus/HPV type 16, 18 and 31 proteins E6.
Belongs to the fibulin family.
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