RNF167 Antibody - #DF9489
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9489, RRID:AB_2842685.
Fold/Unfold
5730408C10Rik; E3 ubiquitin-protein ligase RNF167; LP2254; RING finger protein 167; RING105; RN167_HUMAN; RNF167;
Immunogens
- Q9H6Y7 RN167_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H6Y7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K97 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| Y237 | Phosphorylation | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| R277 | Methylation | Uniprot | |
| T288 | Phosphorylation | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S345 | Phosphorylation | Uniprot |
Research Backgrounds
May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.
Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.
Endomembrane system>Single-pass membrane protein.
Note: Targeted to cytoplasmic membranes.
Strongly expressed in the kidney and liver (at protein level).
Interacts with SLC22A18.
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