DYNLT3 Antibody - #DF9474
| Product: | DYNLT3 Antibody |
| Catalog: | DF9474 |
| Description: | Rabbit polyclonal antibody to DYNLT3 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 13 kDa; 13kD(Calculated). |
| Uniprot: | P51808 |
| RRID: | AB_2842670 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9474, RRID:AB_2842670.
Fold/Unfold
2310075M16Rik; AU042796; DYLT3_HUMAN; Dynein light chain Tctex-type 3; DYNLT3; Protein 91/23; RP23-256J17.2; RP3; T-complex-associated testis-expressed 1-like; Tcte1l; TCTEX1L;
Immunogens
- P51808 DYLT3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEYHRHCDEVGFNAEEAHNIVKECVDGVLGGEDYNHNNINQWTASIVEQSLTHLVKLGKAYKYIVTCAVVQKSAYGFHTASSCFWDTTSDGTCTVRWENRTMNCIVNVFAIAIVL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51808 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| C8 | S-Nitrosylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| T95 | Phosphorylation | Uniprot |
Research Backgrounds
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
Nucleus. Cytoplasm>Cytoskeleton. Chromosome>Centromere>Kinetochore.
Note: Colocalizes with BUB3 at kinetochores specifically during prometaphase.
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.
Belongs to the dynein light chain Tctex-type family.
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