CBX2 Antibody - #DF9380
| Product: | CBX2 Antibody |
| Catalog: | DF9380 |
| Description: | Rabbit polyclonal antibody to CBX2 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Sheep, Rabbit |
| Mol.Wt.: | 56 kDa; 56kD(Calculated). |
| Uniprot: | Q14781 |
| RRID: | AB_2842576 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9380, RRID:AB_2842576.
Fold/Unfold
Cbx 2; CBX2; CBX2_HUMAN; CDC A6; CDCA6; Cell division cycle associated 6; Cell division cycle associated6; chromobox homolog 2 (Pc class homolog, Drosophila); Chromobox homolog 2; Chromobox homolog2; Chromobox protein homolog 2; hromobox homolog 2; M33; M33 polycomb like; MOD 2; MOD2; Modifier 3; Modifier3; Pc class homolog; Polycomb; SRXY5;
Immunogens
- Q14781 CBX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSSSDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLPPEQKATRRPVSLAKVLKTARKDLGAPASKLPPPLSAPVAGLAALKAHAKEACGGPSAMATPENLASLMKGMASSPGRGGISWQSSIVHYMNRMTQSQAQAASRLALKAQATNKCGLGLDLKVRTQKGELGMSPPGSKIPKAPSGGAVEQKVGNTGGPPHTHGASRVPAGCPGPQPAPTQELSLQVLDLQSVKNGMPGVGLLARHATATKGVPATNPAPGKGTGSGLIGASGATMPTDTSKSEKLASRAVAPPTPASKRDCVKGSATPSGQESRTAPGEARKAATLPEMSAGEESSSSDSDPDSASPPSTGQNPSVSVQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14781 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T84 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| K146 | Sumoylation | Uniprot | |
| K153 | Sumoylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K199 | Acetylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| T230 | Phosphorylation | Uniprot | |
| R247 | Methylation | Uniprot | |
| Y259 | Phosphorylation | Uniprot | |
| K277 | Methylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| T281 | Phosphorylation | Uniprot | |
| K283 | Methylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| T294 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| K310 | Ubiquitination | Uniprot | |
| K320 | Sumoylation | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| T423 | Phosphorylation | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K432 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| T436 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot |
Research Backgrounds
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression.
Nucleus. Chromosome.
Note: Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin.
Component of a PRC1-like complex. The composition of the PRC1 complex may differ between the PRC1 complex in pluripotent embryonic stem cells containing RNF2, CBX7 and PCGF2, and the PRC1 complex in differentiating cells containing RNF2, CBX2, CBX4 and BMI1 (By similarity). May interact with HIST2H3A, HIST1H3A and RNF2. Interacts (via chromodomain) with histone H3K9Me3 and H3K27me3 (By similarity).
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