CTNND2 Antibody - #DF9348

(1)  
Product: CTNND2 Antibody
Catalog: DF9348
Description: Rabbit polyclonal antibody to CTNND2
Application: WB
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 133 kDa; 133kD(Calculated).
Uniprot: Q9UQB3
RRID: AB_2842544

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors
Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
Clonality:
Polyclonal
Specificity:
CTNND2 Antibody detects endogenous levels of total CTNND2.
RRID:
AB_2842544
Cite Format: Affinity Biosciences Cat# DF9348, RRID:AB_2842544.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ARM-repeat protein; Catenin (cadherin associated protein) delta 2; catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein); Catenin delta 2; Catenin delta-2; CTND2_HUMAN; CTNND 2; Ctnnd2; Delta catenin; Delta-catenin; GT 24; GT24; Neural plakophilin related arm repeat protein; Neural plakophilin related armadillo repeat protein; Neural plakophilin-related ARM-repeat protein; Neural plakophilin-related, Neurojungin; Neurojungin; NPRAP; T cell delta catenin;

Immunogens

Immunogen:
Uniprot:

Q9UQB3(CTND2_HUMAN) >>Visit HPA database.

Gene(ID):
CTNND2(1501)
Expression:
Q9UQB3 CTND2_HUMAN:

Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484).

Sequence:
MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLAAPQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYRNSYGAPAEDIKHNQVSAQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Horse
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9UQB3 As Substrate

Site PTM Type Enzyme
S43 Phosphorylation
S201 Phosphorylation
S267 Phosphorylation
S276 Phosphorylation
S285 Phosphorylation
Y292 Phosphorylation
S298 Phosphorylation
S303 Phosphorylation
S305 Phosphorylation
Y372 Phosphorylation
Y380 Phosphorylation
Y399 Phosphorylation
S415 Phosphorylation
Y424 Phosphorylation
Y429 Phosphorylation
T457 Phosphorylation P31749 (AKT1)
S461 Phosphorylation
S474 Phosphorylation
S490 Phosphorylation
S497 Phosphorylation
Y499 Phosphorylation
Y503 Phosphorylation
Y508 Phosphorylation
S511 Phosphorylation
S514 Phosphorylation
Y516 Phosphorylation
S517 Phosphorylation
S532 Phosphorylation
S534 Phosphorylation
S537 Phosphorylation
K540 Ubiquitination
K926 Ubiquitination
K931 Ubiquitination
Y932 Phosphorylation
S1002 Phosphorylation
T1042 Phosphorylation
T1056 Phosphorylation P49841 (GSK3B)
S1060 Phosphorylation
S1065 Phosphorylation
S1072 Phosphorylation
Y1090 Phosphorylation
Y1099 Phosphorylation
T1122 Phosphorylation
S1127 Phosphorylation
Y1154 Phosphorylation
Y1157 Phosphorylation
S1193 Phosphorylation
Y1197 Phosphorylation
Y1201 Phosphorylation
Y1207 Phosphorylation
Y1217 Phosphorylation

Research Backgrounds

Function:

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

PTMs:

O-glycosylated.

Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B.

Subcellular Location:

Nucleus. Cell junction>Adherens junction. Cell projection>Dendrite. Perikaryon.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in brain; highest expression is observed in fetal brain.

Subunit Structure:

Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain (By similarity). Interacts with PDZD2 (By similarity). Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with CDK5 (By similarity). Interacts with CTNNB1. Interacts with GSK3A and GSK3B. Interacts with DNM2. Interacts with CCDC85B.

Family&Domains:

Belongs to the beta-catenin family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.