CEACAM7 Antibody - #DF9346

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Product: CEACAM7 Antibody
Catalog: DF9346
Description: Rabbit polyclonal antibody to CEACAM7
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 29kDa; 29kD(Calculated).
Uniprot: Q14002
RRID: AB_2842542

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
CEACAM7 Antibody detects endogenous levels of total CEACAM7.
RRID:
AB_2842542
Cite Format: Affinity Biosciences Cat# DF9346, RRID:AB_2842542.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Carcinoembryonic antigen CGM 2; Carcinoembryonic antigen CGM2; Carcinoembryonic antigen gene family member 2; Carcinoembryonic antigen related cell adhesion molecule 7; Carcinoembryonic antigen-related cell adhesion molecule 7; CEA; CEACAM 7; CEACAM7; CEAM7_HUMAN; CGM 2; CGM2;

Immunogens

Immunogen:
Uniprot:

Q14002(CEAM7_HUMAN) >>Visit HPA database.

Gene(ID):
CEACAM7(1087)
Expression:
Q14002 CEAM7_HUMAN:

Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). Strongly down-regulated in colonic adenocarcinomas.

Sequence:
MGSPSACPYRVCIPWQGLLLTASLLTFWNLPNSAQTNIDVVPFNVAEGKEVLLVVHNESQNLYGYNWYKGERVHANYRIIGYVKNISQENAPGPAHNGRETIYPNGTLLIQNVTHNDAGFYTLHVIKENLVNEEVTRQFYVFSEPPKPSITSNNFNPVENKDIVVLTCQPETQNTTYLWWVNNQSLLVSPRLLLSTDNRTLVLLSATKNDIGPYECEIQNPVGASRSDPVTLNVRYESVQASSPDLSAGTAVSIMIGVLAGMALI

PTMs - Q14002 As Substrate

Site PTM Type Enzyme
Y236 Phosphorylation
S242 Phosphorylation
S243 Phosphorylation
T250 Phosphorylation

Research Backgrounds

Subcellular Location:

Cell membrane>Lipid-anchor. Apical cell membrane.
Note: Localized to the apical glycocalyx surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in columnar epithelial cells of the colon (at protein level). Strongly down-regulated in colonic adenocarcinomas.

Subunit Structure:

Homodimer.

Family&Domains:

Belongs to the immunoglobulin superfamily. CEA family.

References

1). RNA-sequencing expression profile and functional analysis of retinal pigment epithelium in atrophic age-related macular degeneration. Journal of biomedical research, 2024 (PubMed: 38808557) [IF=2.3]

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Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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