CEACAM20 Antibody - #DF9345
| Product: | CEACAM20 Antibody |
| Catalog: | DF9345 |
| Description: | Rabbit polyclonal antibody to CEACAM20 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Dog |
| Mol.Wt.: | 65 kDa; 66kD(Calculated). |
| Uniprot: | Q6UY09 |
| RRID: | AB_2842541 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9345, RRID:AB_2842541.
Fold/Unfold
carcinoembryonic antigen related cell adhesion molecule 20; UNQ9366;
Immunogens
- Q6UY09 CEA20_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGPADSWGHHWMGILLSASLCTVWSPPAAAQLTLNANPLDATQSEDVVLPVFGTPRTPQIHGRSRELAKPSIAVSPGTAIEQKDMVTFYCTTKDVNITIHWVSNNLSIVFHERMQLSKDGKILTILIVQREDSGTYQCEARDALLSQRSDPIFLDVKYGPDPVEIKLESGVASGEVVEVMEGSSMTFLAETKSHPPCAYTWFLLDSILSHTTRTFTIHAVSREHEGLYRCLVSNSATHLSSLGTLKVRVLETLTMPQVVPSSLNLVENARSVDLTCQTVNQSVNVQWFLSGQPLLPSEHLQLSADNRTLIIHGLQRNDTGPYACEVWNWGSRARSEPLELTINYGPDQVHITRESASEMISTIEAELNSSLTLQCWAESKPGAEYRWTLEHSTGEHLGEQLIIRALTWEHDGIYNCTASNSLTGLARSTSVLVKVVGPQSSSLSSGAIAGIVIGILAVIAVASELGYFLCIRNARRPSRKTTEDPSHETSQPIPKEEHPTEPSSESLSPEYRNISQLQGRIRVELMQPPDLPEETYETKLPSASRRGNSFSPWKPPPKPLMPPLRLVSTVPKNMESIYEELVNPEPNTYIQINPSV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6UY09 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S169 | Phosphorylation | Uniprot | |
| S370 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| T569 | Phosphorylation | Uniprot |
Research Backgrounds
Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.
Phosphorylated on tyrosine residues by SYK, SRC and FYN in vitro.
Cell projection>Microvillus membrane>Single-pass type I membrane protein. Apical cell membrane>Single-pass type I membrane protein.
Note: Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells.
Interacts (via extracellular domain) with PTPRH (via extracellular domain); the interaction dephosphorylates CEACAM20. Interacts (phosphorylated form) with SYK (via SH2 domains); the interaction further enhances CEACAM20 phosphorylation.
Belongs to the immunoglobulin superfamily. CEA family.
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