CAPN6 Antibody - #DF9321
| Product: | CAPN6 Antibody |
| Catalog: | DF9321 |
| Description: | Rabbit polyclonal antibody to CAPN6 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 75kDa; 75kD(Calculated). |
| Uniprot: | Q9Y6Q1 |
| RRID: | AB_2842517 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9321, RRID:AB_2842517.
Fold/Unfold
CALP M; Calpain-6; Calpain-like protease X-linked; Calpamodulin; CalpM; CAN6_HUMAN; CANP X; CANPX; CAPN 6; Capn6;
Immunogens
- Q9Y6Q1 CAN6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y6Q1 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y174 | Phosphorylation | Uniprot | |
| T181 | Phosphorylation | Uniprot | |
| T196 | Phosphorylation | Uniprot | |
| Y450 | Phosphorylation | Uniprot | |
| T453 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| Y467 | Phosphorylation | Uniprot | |
| Y540 | Phosphorylation | Uniprot |
Research Backgrounds
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).
Cytoplasm>Perinuclear region. Cytoplasm>Cytoskeleton>Spindle.
Note: During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
Expressed only in placenta.
Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).
Belongs to the peptidase C2 family.
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