COPS3 Antibody - #AF0187
| Product: | COPS3 Antibody |
| Catalog: | AF0187 |
| Description: | Rabbit polyclonal antibody to COPS3 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 47kDa; 48kD(Calculated). |
| Uniprot: | Q9UNS2 |
| RRID: | AB_2833380 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0187, RRID:AB_2833380.
Fold/Unfold
Constitutive photomorphogenic homolog subunit 3; COP 9 (constitutive photomorphogenic) subunit 3; COP 9 complex homolog subunit 3; COP 9 complex S3; COP 9 complex subunit 3; COP 9 constitutive photomorphogenic homolog subunit 3; COP 9 homolog; COP 9 signalosome complex subunit 3; COP 9 signalosome subunit 3; COP 9 subunit 3; COP9 (constitutive photomorphogenic) subunit 3; COP9 complex homolog subunit 3; COP9 complex S3; COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 homolog; COP9 signalosome complex subunit 3; COP9 signalosome subunit 3; COP9 subunit 3; COPS 3; cops3; CSN 3; CSN3; CSN3_HUMAN; JAB 1 containing signalosome subunit 3; JAB1 containing signalosome subunit 3; JAB1-containing signalosome subunit 3; SGN 3; SGN3; Signalosome subunit 3;
Immunogens
- Q9UNS2 CSN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UNS2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| Y367 | Phosphorylation | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cytoplasm. Nucleus.
Widely expressed. Expressed at high level in heart and skeletal muscle.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 isoform 1. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG. Interacts with ERCC6.
Belongs to the CSN3 family.
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