CD226/DNAM-1 Antibody - #AF0087
| Product: | CD226/DNAM-1 Antibody |
| Catalog: | AF0087 |
| Description: | Rabbit polyclonal antibody to CD226/DNAM-1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Monkey |
| Prediction: | Pig, Horse |
| Mol.Wt.: | 38kDa; 39kD(Calculated). |
| Uniprot: | Q15762 |
| RRID: | AB_2833272 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0087, RRID:AB_2833272.
Fold/Unfold
adhesion glycoprotein; CD226; CD226 antigen; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; DNAM1; DNAX accessory molecule 1; platelet and T cell activation antigen 1; PTA1; T lineage specific activation antigen 1 antigen; TLiSA1;
Immunogens
- Q15762 CD226_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15762 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K167 | Ubiquitination | Uniprot | |
| Y249 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| T293 | Phosphorylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| Y322 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | P17252 (PRKCA) | Uniprot |
Research Backgrounds
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
Cell membrane>Single-pass type I membrane protein.
Expressed by peripheral blood T-lymphocytes.
Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.
Research Fields
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.