GPRIN1 Antibody - #AF0664
(2)
| Product: | GPRIN1 Antibody |
| Catalog: | AF0664 |
| Description: | Rabbit polyclonal antibody to GPRIN1 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 102kDa; 102kD(Calculated). |
| Uniprot: | Q7Z2K8 |
| RRID: | AB_2834395 |
Related Downloads
Protocols
Product Info
Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Prediction:
Bovine(100%), Horse(82%), Sheep(100%), Dog(91%)
Clonality:
Polyclonal
Specificity:
GPRIN1 Antibody detects endogenous levels of total GPRIN1.
RRID:
AB_2834395
Cite Format: Affinity Biosciences Cat# AF0664, RRID:AB_2834395.
Cite Format: Affinity Biosciences Cat# AF0664, RRID:AB_2834395.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
G protein regulated inducer of neurite outgrowth 1; G protein-regulated inducer of neurite outgrowth 1; GPRIN1; GRIN1; GRIN1_HUMAN; KIAA1893; Z16;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Expression:
Q7Z2K8 GRIN1_HUMAN:
Widely expressed in the central nervous system, with highest levels in spinal cord.
Description:
GRIN1 May be involved in neurite outgrowth. Interacts with activated forms of GNAI1, GNAO1 and GNAZ. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Sequence:
- Q7Z2K8 GRIN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE
Predictions
Predictions:
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
Species
Results
Score
Bovine
100
Sheep
100
Dog
91
Horse
82
Pig
73
Chicken
71
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7Z2K8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T25 | Phosphorylation | Uniprot | |
| Y45 | Phosphorylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| T97 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| T120 | Phosphorylation | Uniprot | |
| T182 | Phosphorylation | Uniprot | |
| T225 | Phosphorylation | Uniprot | |
| Y226 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| S286 | Phosphorylation | Uniprot | |
| T313 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| T450 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| S476 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| T515 | Phosphorylation | Uniprot | |
| S540 | Phosphorylation | Uniprot | |
| S571 | Phosphorylation | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| S615 | Phosphorylation | Uniprot | |
| T618 | Phosphorylation | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| S704 | Phosphorylation | Uniprot | |
| S706 | Phosphorylation | Uniprot | |
| S714 | Phosphorylation | Uniprot | |
| S734 | Phosphorylation | Uniprot | |
| S737 | Phosphorylation | Uniprot | |
| S744 | Phosphorylation | Uniprot | |
| S776 | Phosphorylation | Uniprot | |
| S799 | Phosphorylation | Uniprot | |
| S850 | Phosphorylation | Uniprot | |
| S853 | Phosphorylation | Uniprot | |
| S862 | Phosphorylation | Uniprot | |
| T873 | Phosphorylation | Uniprot | |
| T877 | Phosphorylation | Uniprot | |
| S895 | Phosphorylation | Uniprot | |
| S914 | Phosphorylation | Uniprot | |
| R962 | Methylation | Uniprot | |
| R967 | Methylation | Uniprot | |
| S968 | Phosphorylation | Uniprot | |
| S970 | Phosphorylation | Uniprot | |
| T973 | Phosphorylation | Uniprot | |
| S993 | Phosphorylation | Uniprot |
Research Backgrounds
Function:
May be involved in neurite outgrowth.
PTMs:
Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.
Subcellular Location:
Cell membrane>Lipid-anchor. Cell projection>Growth cone.
Note: Highly enriched in growth cone.
Tissue Specificity:
Widely expressed in the central nervous system, with highest levels in spinal cord.
Subunit Structure:
Interacts with activated forms of GNAI1, GNAO1 and GNAZ.
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