IRAK3 Antibody - #AF0690
| Product: | IRAK3 Antibody |
| Catalog: | AF0690 |
| Description: | Rabbit polyclonal antibody to IRAK3 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 68kDa; 68kD(Calculated). |
| Uniprot: | Q9Y616 |
| RRID: | AB_2834362 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0690, RRID:AB_2834362.
Fold/Unfold
ASRT5; IL 1 receptor associated kinase M; IL-1 receptor-associated kinase M; IL1 receptor associated kinase M; Interleukin 1 receptor associated kinase 3; Interleukin 1 receptor associated kinase M; Interleukin-1 receptor-associated kinase 3; IRAK M; IRAK-3; IRAK-M; Irak3; IRAK3_HUMAN;
Immunogens
- Q9Y616 IRAK3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y616 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y61 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| Y189 | Phosphorylation | Uniprot | |
| K199 | Acetylation | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| S510 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot |
Research Backgrounds
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Expressed predominantly in peripheral blood lymphocytes.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Research Fields
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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