VPS72 Antibody - #AF0508
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0508, RRID:AB_2834267.
Fold/Unfold
CFL1; HGNC11644; Protein YL-1; Swc2; TCFL1; Transcription factor like 1 (YL1); Transcription Factor Like 1; Transcription factor-like 1; Vacuolar protein sorting 72 (yeast); Vacuolar protein sorting 72 homolog (S. cerevisiae); Vacuolar protein sorting associated protein 72 homolog; Vacuolar protein sorting-associated protein 72 homolog; VPS72; VPS72_HUMAN; YL-1; YL1;
Immunogens
- Q15906 VPS72_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPAPSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15906 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R7 | Methylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| T86 | Phosphorylation | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| T168 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K197 | Acetylation | Uniprot | |
| K198 | Acetylation | Uniprot | |
| K203 | Acetylation | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| Y326 | Phosphorylation | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot |
Research Backgrounds
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Nucleus.
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AZ1/H2AZ. Interacts (via N-terminal domain) with heterodimer H2BC11 and H2AZ1.
Belongs to the VPS72/YL1 family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.