mGluR2/3 Antibody - #AF0167
| Product: | mGluR2/3 Antibody |
| Catalog: | AF0167 |
| Description: | Rabbit polyclonal antibody to mGluR2/3 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 96kDa,99kDa; 96kD,99kD(Calculated). |
| Uniprot: | Q14416 | Q14832 |
| RRID: | AB_2833360 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0167, RRID:AB_2833360.
Fold/Unfold
AMPA selective glutamate receptor 2; GLUR2; GLURB; Glutamate metabotropic receptor 2; Glutamate receptor homolog; Glutamate receptor metabotropic 2; GPRC1B; GRM2; GRM2_HUMAN; Metabotropic glutamate receptor 2; mGlu2; mGluR2; OTTHUMP00000210984; OTTHUMP00000210986; GLUR3; Glutamate metabotropic receptor 3; Glutamate receptor metabotropic 3; GPRC1C; GRM3; GRM3_HUMAN; Metabotropic glutamate receptor 3; MGlu3; mGluR3;
Immunogens
Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
Q14832 GRM3_HUMAN:Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
- Q14416 GRM2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
- Q14832 GRM3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14416/Q14832 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S109 | Phosphorylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| T457 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| S675 | Phosphorylation | Uniprot | |
| Y734 | Phosphorylation | Uniprot | |
| Y745 | Phosphorylation | Uniprot | |
| T749 | Phosphorylation | Uniprot |
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S255 | Phosphorylation | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| Y743 | Phosphorylation | Uniprot | |
| Y754 | Phosphorylation | Uniprot | |
| T758 | Phosphorylation | Uniprot |
Research Backgrounds
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Cell membrane>Multi-pass membrane protein. Cell junction>Synapse. Cell projection>Dendrite.
Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
Interacts with GRASP (By similarity). Interacts with HTR2A.
Belongs to the G-protein coupled receptor 3 family.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Cell membrane>Multi-pass membrane protein.
Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
Interacts with GRASP.
Belongs to the G-protein coupled receptor 3 family.
Research Fields
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Substance dependence > Cocaine addiction.
· Organismal Systems > Nervous system > Glutamatergic synapse.
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