TRIP13 Antibody - #AF0570
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0570, RRID:AB_2834261.
Fold/Unfold
16E1-BP; 16E1BP; Homo sapiens HPV16 E1 protein binding protein mRNA complete cds; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; Human papillomavirus type 16 E1 protein binding protein; Human papillomavirus type 16 E1 protein-binding protein; Pachytene checkpoint protein 2 homolog; PCH2; Thyroid hormone receptor interactor 13; Thyroid receptor interacting protein 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13; Trip13; TRP13_HUMAN;
Immunogens
- Q15645 PCH2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQPIDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLAAYI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15645 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| Y56 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| T183 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| Y206 | Phosphorylation | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| S370 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation.
Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with HPV16 E1. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity).
Belongs to the AAA ATPase family. PCH2 subfamily.
References
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